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Multaq : Liver function tests indicate how well the liver is performing par­ticular functions and the levels of certain measurements associated with inflammation.

Dozens of different LFTs are performed in hospitals, but they all measure the levels of liver proteins, liver enzymes (called trans­aminases and cholestatic liver enzymes), and bilirubin.

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Transamines: AST and ALT

Liver function tests that check the levels of aspartate transaminase (AST) and alanine transaminase (ALT) are looking for inflamma­tion or injury to liver cells-—-in technical terms, hepatocellular liver injur)’’. When the liver is damaged, AST and ALT often leak into the bloodstream, so a blood test result that detected transamines would be a possible indicator of liver damage. However, AST is also found in the heart, kidneys, and muscles, so an elevated amount of AST doesn’t always mean a liver problem. When it is coupled with elevated ALT, which exists only in the liver, a higher AST level indicates that liver damage is more probable.

The extent of liver damage cannot be determined by high transaminase levels alone. If a patient drinks alcohol a few hours before the blood test or works out in the gym the morning his or her blood is drawn, the transaminase levels may be mildly elevated. On the other hand, if alcohol abuse damaged the liver five years ago, the transaminase level may be normal, but still there could be residual liver damage.

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Moreover, men tend to have higher transaminase levels than women, and African American men usually show higher AST and ALT levels than Caucasian men. Almost everyone’s transaminase levels are higher in the morning than they are later in the day.

High, levels of AST and ALT serve as the first clues along a path of diagnostic testing to pinpoint what is wrong. Elevated transami­nase levels might indicate strenuous exercise or recent alcohol use, but they could also be caused by a fatty liver, alcoholic liver dis­ease, viral hepatitis, autoimmune hepatitis, a genetic liver disease, a tumor, heart or lung failure, or some toxic injury to the liver.

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